New research suggests that patients who come off blockbuster weight-loss injections like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who halt traditional diet and exercise regimens.
Findings released in a leading health publication shows that while obese individuals frequently drop substantial amounts of their total mass while on the medication, the weight comes back at an estimated rate of 0.8 kg per month once they quit.
"Users purchasing these drugs need to be aware of the risk of rapid rebound weight gain when the therapy ends," warns researcher Dr. Susan Jebb.
Such speed of regain implies a return to original mass in about 18 months.
Weighing Treatments
The analysis, which examined dozens of studies involving over 9,000 of participants, contrasted the effects of these new drugs with other pills.
Researchers point out that people who shed pounds through diet and exercise generally see a less rapid weight regain—around 0.1 kg a month—post-intervention.
Understanding the Quick Rebound
Doctors suggest the way of the jabs is key to understanding the amplified weight return.
GLP-1 drugs copy a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Sustained high doses of the hormone concentrations several times higher than the body's typical production might result in the system to produce less of its endogenous GLP-1, and could diminish responsiveness to its actions," said Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication means appetite is uncontrolled, making excessive eating a significant risk."
A Chronic Condition?
Medical guidelines advise the jabs for people with weight-linked medical conditions, alongside prescribed lifestyle changes.
A number of clinicians contend that, due to the high risk of relapse, the treatment should be considered long-term.
This perspective is reinforced by drug manufacturers, who say that the findings "highlight the persistent character of excess weight," comparing it to managing diseases like high blood pressure.
User Accounts
People who have stopped the jabs report a sudden return of cravings.
"It was like a switch flipping and you're instantly extremely hungry," recalled one woman.
This challenge is compounded if patients have not established lasting lifestyle or habit modifications during therapy.
Widespread Interest
Survey data indicate that millions of adults in the UK have tried weight-loss jabs in the past year, with demand continuing to grow.
- Use is higher among women compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many access the medications through private healthcare rather than the NHS.
Ultimately, experts emphasize that while the jabs are powerful tools for shedding pounds, they are not a magic cure and maintained weight loss relies on ongoing lifestyle changes.
